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Revista de la Facultad de Medicina Humana
Print version ISSN 1814-5469On-line version ISSN 2308-0531
Abstract
-VARGAS, Milagros Fuentes et al. Effect of orchidectomized and exogenous administration of testosterone on the quantification of platelets in male Wistar rats. Rev. Fac. Med. Hum. [online]. 2021, vol.21, n.4, pp.749-757. ISSN 1814-5469. http://dx.doi.org/10.25176/rfmh.v21i4.4042.
Introduction:
Anabolic-androgenic steroids (AAS) modify the physiological functioning of the cardiovascular system and have possible effects on the origin of cardiovascular thrombosis.
Objective:
To determine the impact of the testosterone metabolite on platelet quantification in ORX rats with or without DHT replacement.
Material and methods:
24 male 45-day-old Wistar rats underwent orchidectomy with a simple scrotal incision. At 2.5 months of age, the 24 rats were divided into 4 study groups. Half of the 12 male ORX rats received hormone replacement with dihydrotestosterone propionate (DHT) at a 2 mg/kg dose via subcutaneous injection for 7 days and the other half received a physiological solution (0.9% NaCl). The same occurred in the 12 non-ORX males (SHAM). After 7 days of the administration, blood was collected by orbital puncture, and platelet quantification was performed.
Results:
A significant difference (ANOVA, p < 0.005) was found between the 4 groups. When performing the Dunn Method, a significant difference (p < 0.05) was found in the endogenous administration of DHT between Sham rats and rats ORX + 0.9% NaCl but not with ORX + DHT.
Conclusions:
DHT induces an increase in platelet quantification inrats Sham and not in ORX rats with DHT, which may affect the increase in platelet quantification.
Keywords : Androgens; testosterone; anabolic; hemostasis, platelets, DHT. (Source: MeSH NLM)..