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Revista Peruana de Medicina Experimental y Salud Publica
versión impresa ISSN 1726-4634
Resumen
BURELA, Alejandra et al. Chlorine dioxide and chlorine derivatives for the prevention or treatment of COVID-19: a systematic review. Rev. perú. med. exp. salud publica [online]. 2020, vol.37, n.4, pp.605-610. Epub 07-Sep-2020. ISSN 1726-4634. http://dx.doi.org/10.17843/rpmesp.2020.374.6330.
Objectives:
To systematically review the effectiveness and safety of chlorine dioxide solution and chlorine derivatives used in the prevention or treatment of COVID-19.
Methods:
This review adheres to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) and follows the guidelines provided in the Cochrane Handbook for Systematic Reviews of Interventions. A librarian developed and executed the search strategy; it was further reviewed by two of the authors and complemented by manual search. Randomized clinical trials, quasi-experimental studies, cohort studies, case-control studies, cross-sectional studies, and case reports were included; in vitro or animal studies were excluded. Abstract and full-text screening according to pre-defined eligibility criteria were performed by two reviewers independently using web application Rayyan QCRI. Disagreements on study selection were resolved by a third reviewer. The systematic review protocol was registered in PROSPERO (CRD42020200641).
Results:
Neither published nor pre-print studies evaluating the use of chlorine dioxide or derivatives on SARS-CoV-2 infection were identified. The only finding was an unpublished observational study registry which has no results released yet.
Conclusions:
To date, there are no scientific evidence to uphold the use of chlorine dioxide or derivatives as preventive or therapeutic agents against COVID-19.
Palabras clave : Chlorine Dioxide; Chlorine Compounds; Prevention and Control; Severe Acute Respiratory Syndrome Coronavirus 2; COVID-19; SARS-CoV-2 infection.