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Revista Peruana de Medicina Experimental y Salud Publica
versión impresa ISSN 1726-4634
Resumen
GARCIA-MENDOZA, María et al. IgG antibody response by ELISA using Wuhan and Lambda variant antigens in BBIBP-CORV vaccinated health care workers. Rev. perú. med. exp. salud publica [online]. 2022, vol.39, n.3, pp.267-273. Epub 30-Sep-2022. ISSN 1726-4634. http://dx.doi.org/10.17843/rpmesp.2022.393.10875.
Objectives
. To evaluate the IgG antibody response by ELISA using Wuhan and Lambda antigens in health care workers with and without history of SARS-CoV-2 infection prior to immunization with the first and second doses of Sinopharm vaccine (BBIBP-CorV).
Materials and methods
. An analytical study was carried out in health care workers over 18 years of age. Fifty-one participants with history and 100 participants without history of SARS-CoV-2 infection, who received two doses of Sinopharm vaccine, were included. IgG antibodies were assessed 21 days after the first dose, 21 days after the second dose and 3 months after the second dose by in-house ELISA using the complete antigen of the Wuhan variant (B.1.1) and lambda variant (C-37) of SARS-CoV-2 virus.
Results
. Both groups showed a large increase in the percentage of people with antibodies after the second dose, however, this percentage decreased 3 months after the second dose. The difference between the antibody index measured by ELISA with Wuhan variant antigen versus the ELISA with lambda variant was significant (p<0.001).
Conclusions
. There is a significant increase in the presence of IgG type antibodies after 15 days of the second dose of BBIBP-CorV vaccination in participants without previous infection and a decrease after 3 months of the second dose in the ratio of IgG antibody reactivity indexes in ELISAs with the variant antigen as with ELISAs with the lambda variant.
Palabras clave : Coronavirus infections; Immunity Humoral; SARS-CoV-2 C.37 variant; Peru.