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Revista de la Facultad de Medicina Humana
versión impresa ISSN 1814-5469versión On-line ISSN 2308-0531
Resumen
CASTILLO VEGA, María Alejandra y MEJIA SANCHEZ, Gilmar Robert. Use of inhaled corticoids as a risk factor for community-acquired pneumonia in patients with chronic obstructive pulmonary disease. Rev. Fac. Med. Hum. [online]. 2023, vol.23, n.3, pp.15-21. Epub 21-Sep-2023. ISSN 1814-5469. http://dx.doi.org/10.25176/rfmh.v23i3.5604.
Objective:
To determine if the use of inhaled corticosteroids is a risk factor for community-acquired pneumonia in patients with Chronic Obstructive Pulmonary Disease at the Víctor Lazarte Echegaray Hospital during the period 2017-2020.
Methods:
The study was analytical, observational, retrospective of cases and unmatched controls in a ratio of 4:, with a population of 405 subjects from whom 81 cases and 324 controls were selected, who met the selection criteria. A non-probabilistic sampling was carried out. The variables, use of inhaled corticosteroids, patients with community-acquired pneumonia, age, sex, malnutrition and smoking were included. The association was measured using Pearson's non-parametric Chi-square test and Fisher's exact test at lower frequencies less than 5. The bivariate and multivariate analysis was performed using multiple logistic regression with statistical significance (p value < 0.05). The study statistician was the odds ratio (OR).
Results:
Through the multivariate analysis of the variables under study, no relationship was found between the use of inhaled corticosteroids and patients with community-acquired pneumonia (OR= 1.17; 95%CI: 0.48-2.99 and p value=0.737). It was observed that only age can be considered as a risk factor in view of its significance (OR=1.09; 95%CI: 1.06-1.12 and p value<0.001), while the variables sex, malnutrition, and smoking proved not to be significant ( p > 0.05).
Conclusion:
The use of inhaled corticosteroids is not a risk factor for community-acquired pneumonia in patients with chronic obstructive pulmonary disease.
Palabras clave : Chronic obstructive pulmonary disease (COPD); corticosteroids; pneumonia.