SciELO - Scientific Electronic Library Online

 
vol.74 número3Impacto de la fortificación de la harina de trigo con ácido fólico en los defectos del tubo neural, en Lima, Perú índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

  • Não possue artigos citadosCitado por SciELO

Links relacionados

  • Não possue artigos similaresSimilares em SciELO

Compartilhar


Anales de la Facultad de Medicina

versão impressa ISSN 1025-5583

Resumo

MARCA, Victoria et al. Association between apolipoprotein E (ApoE) genetic polymorphism and Parkinson’s disease. An. Fac. med. [online]. 2013, vol.74, n.3, pp.169-174. ISSN 1025-5583.

Introduction: Due to the increase in life expectancy in our country, it is necessary to study risk factors for Parkinson’s disease (PD), including apolipoprotein E (ApoE) gene, as this association is not known in our country. Objectives: To determine association of ApoE gene polymorphism and PD. Design: Associative, observational case-control analytic study. Setting: Instituto Nacional de Ciencias Neurologicas, Lima, Peru. Participants: Male and females with and without Parkinson's disease. Interventions: Genomic DNA was extracted from 163 patients and 176 controls. PCR_RFLP technique was used for ApoE gene genotyping. Main outcome measures: ApoE gene genotype and allele frequencies in cases and controls, association and risk. Results: No significant ApoE genotype differences between the control group and patients were found. Allele ε4 frequency was similar in patients and controls: 6.5 and 6.0. Odds ratio for ApoE ε4 allele associated with PD was 1.2163 (IC 95%, 0.6574-2.2507). Conclusions: ApoE ε4 allele could not be considered a risk factor for PD in the population studied.

Palavras-chave : Parkinson's disease; alleles; apolipoprotein E.

        · Espanhol ( pdf )