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Anales de la Facultad de Medicina
versão impressa ISSN 1025-5583
Resumo
SANCHEZ-PEREZ, Jorge A; BEJAR CASTILLO, Vilma; VILLANUEVA COTRINA, Fredy e GUEVARA-GRANADOS, José M.. Antimicrobial activity of secondary metabolites of Aspergillus fumigatus sensu stricto on clinical strains of Staphylococcus aureus and Streptococcus pneumoniae. An. Fac. med. [online]. 2020, vol.81, n.2, pp.180-185. ISSN 1025-5583. http://dx.doi.org/10.15381/anales.v81i2.16170.
Introduction
. The antibiotic resistance of Gram positive bacteria is a serious public health problem where some palliative measures can be found in the antimicrobial principles of filamentous fungi.
Objective.
: To evaluate the antimicrobial activity of secondary metabolites of a clinical isolation of Aspergillus fumigatus on clinical strains of Staphylococcus aureus and Streptococcus pneumoniae.
Methods
. The liquid fermentation of A. fumigatus was carried out in a liquid broth sulfate, potato and dextrose; using ethyl acetate for the extraction of secondary metabolites. The antimicrobial activity considered as a halo greater than 6 mm was evaluated using the diffusion disk methodology.
Results
. A mean of 24,02 ± 2,51 mm and 23,62 ± 4,68 mm was obtained on sensitive and resistant Staphylococcus aureus, respectively. For Streptococcus pneumoniae sensitive and non-susceptible, the means were 25,82 ± 4,05 mm and 26,5 ± 5,39 mm, respectively.
Conclusions
. The crude extract of A. fumigatus has secondary metabolites of alkaloid nature and unsaturated sterols with antimicrobial activity.
Palavras-chave : Antibacterial agents; Microbial Sensitivity Tests; Aspergillus fumigatus; Alkaloids; Staphylococcus aureus; Streptococcus pneumoniae.