SciELO - Scientific Electronic Library Online

 
vol.68 número3Angiogénesis pulmonar mediada por adenosina vía CXCL1/CXCR2El extracto etanólico de las flores de Laccopetalum giganteum (pacra-pacra) aumenta la fertilidad en ratas índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

  • No hay articulos citadosCitado por SciELO

Links relacionados

  • No hay articulos similaresSimilares en SciELO

Compartir


Anales de la Facultad de Medicina

versión impresa ISSN 1025-5583

Resumen

LAURENTE, Jonny et al. Neurotoxic effects of thimerosal at vaccines doses on the encephalon and development in 7 day-old hamsters. An. Fac. med. [online]. 2007, vol.68, n.3, pp.222-237. ISSN 1025-5583.

Objectives: To determine if thimerosal administration in amounts equivalent to vaccines content produces neurotoxic effects on the encephalon in postnatal hamsters and on experimentation animals' development. Design: Experimental, prospective, bietapic study. Setting: San Fernando Faculty of Medicine, Universidad Nacional Mayor de San Marcos. Biologic material: Seven-day old hamsters. Material: We divided 45 postnatal hamsters in three groups: group A (n = 15), group B (n = 15) and group C (n = 15). We administered three intramuscular equivalent doses of sucrose and thimerosal in 20 µL of physiological serum respectively to groups B and C on birth-days 7 (0,227 µg), 9 (0,216 µg) and 11 (0,220 µg). Group A received only 20 µL of saline solution. Main outcome measures: Body weight, encephalon weight, hamster's stature and encephalon histopathological alterations. Results: Anova and student t tests showed statistical significance in favor of low body weight, low encephalon weight and smaller stature in group C with respect to groups A and B hamsters (p<0,000). χ2 statistical significance in relation to the presence of histopathological alterations in group C was also obtained (p<0,000). We observed greater relative risk of encephalic alterations in group C. Conclusions: The administration of thimerosal in doses equivalent to vaccines content was associated with low corporal weight, low encephalon weight and smaller stature in postnatal hamsters. Neurotoxic effects were also produced at encephalic level, at hippocampus (regions CA1, CA3, DG), cerebral cortex and cerebellum (Purkinje cells and granuloses cells) with decrease in neuronal density, neuronal necrosis, axonal dismyelinization and gliosis. In addition, risk increase in developing any of these alterations was high in the animal group receiving thimerosal.

Palabras clave : Vaccines; thimerosal; mesocricetuss; ethylmercury compounds; mercury poisoning; nervous system.

        · resumen en Español     · texto en Español     · Español ( pdf )

 

Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons