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Revista de Neuro-Psiquiatría
versión impresa ISSN 0034-8597
Resumen
GUILLEN PINTO, Daniel y GUILLEN MENDOZA, Daniel. West Syndrome, experience in a case series with access to first line medication, in Lima. Rev Neuropsiquiatr [online]. 2015, vol.78, n.2, pp.65-72. ISSN 0034-8597.
Objectives: To describe the clinical characteristics of a seriesof patients with West Syndrome (WS) with access to first line medication. Material and Methods: Retrospective observational study of children treated between 1996 and 2014. Results: 37 cases were included, with an average starting age of 6.4 months, predominantly males (75.7%), the majority was from Lima. The most common etiology was secondary (83.8%), as prenatal, brain malformations, Tuberous Sclerosis, Down syndrome and perinatal causes. The WS was controlled in 67.6% of the cases; Vigabatrinand ACTH were effective in 20/32 (62.5%). Two patients were controlled with Levetiracetam, one with Topitamate, one with Lamotrigine and one with surgery. Hypsarrhythmia was the predominant electroencephalographic pattern 23/37 (64.9%). Neurologic comorbidities were very frequent (97.3%) and they were mild only in 7/37 (18.9%). Two patients passed away. Conclusions: In this series, the WS had a secondary cause and was efficiently controlled with Vigabatrin or ACTH, therefore, we recommend their inclusion in the national request
Palabras clave : West syndrome; children; epilepsy; vigabatrine; ACTH; levetiracetam; Peru.