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Revista de Neuro-Psiquiatría

Print version ISSN 0034-8597


CASTRO-SUAREZ, Sheila et al. Seizures in the dementia of the Alzheimer disease. Rev Neuropsiquiatr [online]. 2015, vol.78, n.2, pp.86-92. ISSN 0034-8597.

Alzheimer's disease and epilepsy not only share advanced age as a risk factor, also mechanisms underlying in their etiology. The seizures usually occur in late stages of Alzheimer's disease; however patients with familial Alzheimer's disease have even greater risk for seizures, which have been found in patients with mutations in PSEN1, PSEN2 or APP developing seizures even in early stages of the disease. Furthermore temporal lobe epilepsy per se could generate memory impairment and hippocampal sclerosis generatere organization of excitatory and inhibitory neural networks that would result in seizure activity. Is important to recognize patients with Alzheimer's disease and epilepsy for initiate early treatment and prevent further cognitive impairment and improve the quality of life of these patients.

Keywords : Alzheimer´s disease; dementia; epilepsy; seizure.

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