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Revista de Neuro-Psiquiatría

Print version ISSN 0034-8597


TORRES-RAMIREZ, Luis; SARAPURA-CASTRO, Hugo; COSENTINO-ESQUERRE, Carlos  and  VELEZ-ROJAS, Miriam. Corticobasal syndrome as a clinical spectrum of a sporadic Creutzfeldt-Jakob disease. Rev Neuropsiquiatr [online]. 2015, vol.78, n.3, pp.171-175. ISSN 0034-8597.

Creutzfeldt-Jakob disease (CJD) is a neurodegenerative disease characterized by rapidly progressive dementia, myoclonus, motor impairment and typical features on complementary tests; however, unusual clinical features might be associated. Were port one case of sporadic CJD associated with corticobasal syndrome characterized by asymmetric limb apraxia, cortical sensory impairment, alien limb phenomenon, bradykinesia and rigidity; which is the classic clinical spectrum of the corticobasal degeneration. In addition, findings in electroencephalography (EEG), brain magnetic resonance imaging (MRI) and positive CSF protein 14-3-3 were compatible with probable sporadic CJD. This case suggest that asymmetric neurologic impairment may be associated with sporadic CJD

Keywords : Corticobasal degeneration; Creutzfeldt-Jakob syndrome; dementia; prions.

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