Abstract

RICAPA, Miguel A; GUIMAS, Luis B  and  TICSE, Ray. Metabolic profile and associated factors among patients with schizophrenia under antipsychotic treatment attending an outpatient service at the National Institute of Mental Health (Peru). Rev Neuropsiquiatr [online]. 2016, vol.79, n.4, pp.216-229. ISSN 0034-8597.  http://dx.doi.org/10.20453/rnp.v79i4.2976.

Objectives: To describe the metabolic profile and its associated factors among patients with schizophrenia under antipsychotic treatment, seen in the outpatient service at the National Institute of Mental Health “Honorio Delgado-Hideyo Noguchi”, during a period of 3 months. Material and Methods: Cross-sectional study, carried out from May to July 2015. By consecutive sampling, patients with schizophrenia who were receiving the same antipsychotic treatment for at least three months were included. Anthropometric measures were taken, and medical data were obtained from the patients and their medical records. For descriptive statistics purposes, frequencies and measures of central tendency were estimated. To determine the metabolic profile-associated factors, bivariate and multivariate analyses were performed with the Metabolic Syndrome (MS) as a dependent variable. Results: From a total of 272 patients evaluated, 40.8% met the modified ATP-III criteria for MS, 6.3% had type 2 diabetes mellitus, 8.1% had hypertension, 43% were overweight, 28.7% were obese and 74.3% had at least one lipid disorder. MS was significantly associated with age, family history of myocardial infarction (MI), body mass index (BMI) and use of polytherapy with atypical antipsychotics. Conclusions: The frequency of MS found in our sample of schizophrenic patients was high and was associated to a variety of factors whose evaluation is indispensable for an integral and adequate treatment of every patient.

Keywords : Schizophrenia; metabolic syndrome X; antipsychotics agents.

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