Abstract

CABRERA, Santiago AS; MICHEL, Chantal  and  CRUZADO, Lizardo. High risk clinical states for schizophrenia and other forms of psychosis: A brief review. Rev Neuropsiquiatr [online]. 2017, vol.80, n.1, pp.42-59. ISSN 0034-8597.  http://dx.doi.org/10.20453/rnp.v80i1.3059.

Schizophrenia and related psychotic conditions are complex disorders that generally emerge during the transition from adolescence to adulthood, so that their consequences may be deleterious and produce a high number of years of life lost due to disability. An important prognostic factor is the time elapsed between the onset of the disease and the beginning of pharmacological treatment, reason for which the early detection of the disease is an essential factor. This review examines historical aspects, neurobiological findings and conceptions about the high risk clinical stages for the development of schizophrenia. . In the field of clinical prediction, Huber and Gross’ “basic symptoms” model, and Mc Gorry et al’s “ultrahigh risk criteria for schizophrenia” model are presented. Debates about and results of both pharmacological and psychotherapeutic approaches are examined and the need to utilize detection protocols of the preclinical phases of schizophrenia and other psychoses in our country is strongly emphasized.

Keywords : Schizophrenia; schizophrenic spectrum; psychotic disorders; early diagnosis.

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