Abstract

PALOMINO-LESCANO, Henry Y; DE LA CRUZ, Walter; SEGURA-CHAVEZ, Darwin  and  DELGADO-RIO, José C. Encephalitis by anti-N-Methyl-D-Aspartate receptor antibodies and DRESS syndrome secondary to phenytoin: A case report. Rev Neuropsiquiatr [online]. 2017, vol.80, n.3, pp.200-205. ISSN 0034-8597.  http://dx.doi.org/10.20453/rnp.v80i3.3157.

N-Methyl-D-Aspartate receptor encephalitis is a potentially treatable entity characterized by neuropsychiatric symptoms including epileptic seizures, disruption of consciousness, catatonia, and autonomic disorders, and triggered by an immunological response mediated by an antigen. In turn, the DRESS syndrome (Drug Reaction with Eosinophilia and Systemic Symptoms) is a delayed cell-mediated hypersensitivity reaction, frequently associated with antiepileptic aromatic drugs. The case is presented of a young patient who debuted with epileptic seizures initially drug-sensitive, developedthen DRESS syndrome secondary to the use of phenytoin, and later presented disorders of memory and language, behavioral alterations and catatonic state, and presented anti- NMDA receptor antibodies in CSF. Both entities responded to corticoid immuno-therapy, which could contribute to explain a pathogenic association between these two immunomediated entities.

Keywords : Antibodies; Anti-N-Methyl-D-aspartate receptors; catatonia; encephalitis; neuropsychiatric symptoms; N-methyl-D-aspartatereceptor.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )