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Revista de Neuro-Psiquiatría

Print version ISSN 0034-8597


HUARCAYA-VICTORIA, Jeff. Are soft neurological signs relevant in schizophrenia? : A review of current evidence. Rev Neuropsiquiatr [online]. 2017, vol.80, n.4, pp.225-238. ISSN 0034-8597.

Schizophrenia is a disorder that includes multiple signs and symptoms in different areas or domains (positive, negative, affective, motor, cognitive, among others). From them, the motor dimension has acquired remarkable importance during the last decades. Among these motor disorders, the so-called neurological soft signs (NSS) are of particular interest, as they have been identified as possible endophenotypic expressions of schizophrenia, due to their high prevalence in patients with this disorder, and in their closest relatives. These neurological abnormalities are associated with negative symptoms and behavioral disorganization, besides neurocognitive impairment and poor functional performance. In addition, NSS would allow a differentiation between several subgroups of schizophrenic patients, with specific features regarding treatment, follow-up, social and neurocognitive rehabilitation. Likewise, neuroimaging studies have revealed a great variety of structural and functional alterations linked to the heterogeneity of NSS. This article is an updated review of the literature on the topic in an attempt to provide a general perspective of the most representative studies.

Keywords : Soft neurological signs; psychosis; schizophrenia.

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