Resumo

CASAVILCA-ZAMBRANO, Sandro; CANCINO-MALDONADO, Karina; JARAMILLO-VALVERDE, Luis  e  GUIO, Heinner. Epigenetics: The relationship of the environment and mental health. Rev Neuropsiquiatr [online]. 2019, vol.82, n.4, pp.266-273. ISSN 0034-8597.  http://dx.doi.org/10.20453/rnp.v82i4.3648.

The study of the human genome, when performed only through the DNA sequence information, does not completely explain the high level of inter-individual variation usually observed. It is the control of gene expression by the epigenetics what allows to explain those variations of gene expression, as a reversible and hereditary process in the short term under the influence of the environment during various stages of development and adulthood, without modifying the genetic sequence. Epigenetic alterations are already being studied as valuable candidates in the eventual identification of biomarkers. Furthermore, their reversible nature makes them promising factors in the amelioration of disease symptoms through the use of therapeutic approaches. This article explains the epigenetic mechanisms and its relationship with the environment, diet, and its influence on evolution, the occurrence of diseases, human behavior and mental health.

Palavras-chave : Epigenetics; gene expression; evolution; environment; mental health.

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