Revista Medica Herediana
ISSN 1018-130X versión impresa
Objective: To determine the presence of the progesterone receptors in meningiomas and its frequency by means of immunohistochemistry. Material and methods: We studied 24 samples coming from patients who have been operated at the Instituto Nacional de Enfermedades Neoplasicas in Lima, Perú, between 1992 and 1992 because of the presence of a cerebral tumor which gave the final diagnosis of meningioma on the pathology report. The determination of the presence of these receptors was done by the immunohistochemical technic on meningioma tissue previously fixed on paraffin. Results: From the 24 cases studied we have found nine to be positive to progesterone receptors which represented the thirty seven per cent of the total of meningioma samples analyzed. We have observed a marked predominance in the female group which represented eight of the nine positive cases. Conclusions: The use of this recent developed technic of immunohistochemistry applied to fixed tissue in paraffin has permitted us to confirm the presence of progesterone receptors in meningiomas with an elevated frequency which merits a more ample study in a systematic way which should include a therapeutic approach with the use of antiprogestagens like Mifepristone or RU 486. From this study not only recently operated patients could be beneficiated but also those who have been operated in the past and that could be detected as carriers of progesterone receptors with the application of this new technic. (Rev Med Hered 1995; 6: 121-130).
Palabras llave: Progesterone receptor; meningioma; immunohistochemistry.
Universidad Peruana Cayetano Heredia
Facultad de Medicina "Alberto Hurtado"
Av. Honorio Delgado 430 Urb. Ingenieria, San Martin de Porres
Lima 100 - Peru