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Revista Medica Herediana

Print version ISSN 1018-130X


FUKUDA SHARIZAWA, Juan et al. Streptococcus pneumoniae resisting to penicilin in Lima Peru. Rev Med Hered [online]. 1996, vol.7, n.1, pp.11-16. ISSN 1018-130X.

Objective: To evaluate the prevalence of resistance of Streptococcus pneumoniae strains to penicillin. Material y methods: A multicentric transversal survey was performance between November 1993 to November 1994, in four hospitals of Lima-Perú. Samples of sputum, blood, CSF, and other fluids were collected from the microbiology laboratories of those centers. Susceptibility tests of the strains were performed by conventional methods in the laboratory of the Instituto de Medicina Tropical, 61 strains were included. Results: Only 2 (3.3%) of the strains isolated were resistant (minimal inhibitory concentration, MIC>0.12 µg/mL). No high level resistant strains (MIC >2.0 µg/mL) were found in these samples. The other 59 (97.8%) strains were susceptible to penicillin (MIC range: 0.006-1.0 µg/mL). Both penicillin-resistant strains were susceptible to cefotaxime (MIC = 0.251 µg/mL), trimethoprin/sulfamethoxazole (MIC = 8 µg/mL, 16 µg/mL), chloramphenicol (MIC = 1.0 µg/mL); Both strains were resistant to ampicillin, (MIC = 0.5 µg/mL, 1µg/mL). Four (6.6%) strains were resistant to ampicillin, (MIC: 0.06 - 4.0 µg/mL). One strain was (1.7%) resistant to Chloramphenicol, (MIC: 1.0 - 32.0 µg/mL). Only 1 (1.7%) was resistant to Trimethoprin/Sulfamethoxazole, (MIC: 1.00 - 32 µg/mL). All the strains were susceptible to Cefotaxime (MIC range: 0.007-0.251 µg/mL). (Rev Med Hered 1996; 7: 11-16).

Keywords : Penicillin - resistant; Streptococcus pneumoniae; minimal inhibitory concentration; MIC.

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