Revista Medica Herediana
Print ISSN 1018-130X
Objective: To compare the clinical and side effects of two therapeutics schedules in the treatment of asthmatic crisis: The association of fenoterol 100 ug Metered Dose Inhaler (MDI) with spacer device plus dexamethasone IV and salbutamol 10 ug MDI with spacer device plus hydrocortisone IV. Material and Methods: In a ramdomized, prospective, longitudinal, open and multicentric trial we included 60 children with mild-moderate asthmatic crisis (30 for each group). Both groups were comparables at initial evaluation. Results: There were no significative difference in respiratory rate, clinical score, peak expiratory flow rate (PEF), and tremor (p>0.05). We found more heart rate at first 30 and 60 minutes in Fenoterol - Dexamethasone group (p£ 0.05). There were no significative differences in the amount of discharges from hospital at the end of the study (4 hours). Conclusions: We conclude that the association Fenoterol-dexamethasone and Salbutamol-Hydrocortisone are equally effective in the management of mild to moderate asthmatic crisis in children. (Rev Med Hered 1997; 8: 5-10).
Keywords: Fenoterol; salbutamol; dexamethasone; hydrocortisone; asthma; children.
Universidad Peruana Cayetano Heredia
Facultad de Medicina "Alberto Hurtado"
Av. Honorio Delgado 430 Urb. Ingenieria, San Martin de Porres
Lima 100 - Peru