Abstract

DIAZ-PLASENCIA, Juan et al. Clinical pathological picture and prognostic factors for survival in adults with soft ttissue sarcoma. Rev Med Hered [online]. 1997, vol.8, n.4, pp.129-141. ISSN 1018-130X.

Objective: The main objective was to identify the clinico-pathologic-picture and the influence on prognosis of some variables. Material and methods: We analized retrospectively the files of 44 adults patients with soft -tissue sarcomas managed at Belen Hospital, Peru, between 1967 and 1994. Estimation of survival was made by the method of Kaplan - Meier and to assesss the prognostic variables we used the log-rank test. Results: The median age was 46± 19 years (range, 16 to 85 years) and there were 21 males and 23 females (M:F, 0.9:1). The most common complaints were tumor and pain. Twenty - three tumors (52%) were located in the lower and 9 (21%) in the upper extremities. Most patients were classified in UICC stage II (48%), followed by stage III (23%), stage IV (18%) and stage I (11%). The majority of tumors were fibrosarcomas (34%), liposarcomas and rhabdomyosarcomas (14%). Thirteen tumors (30%) were classified as high - grade, 24 (55%) as intermediate - grade and 7 (16%) as low - grade. Twenty - seven patients underwent surgery, 13 received adjuvant chemotherapy and/or radiotherapy, and 4 were treated with primary chemotherapy and/or radiotherapy with 5 - year survival rates of 54%, 11 %, and 0%, respectively. The 5 - year survival rate for the entire group was 38%. According to an univariate analysis of the dependence of survival on variables, the following factors were significant: Age (p < 0.01), lenght of disease (p < 0.001), site (p < 0.001), lymph node status (p< 0.001), histologic grade (p< 0.01), clinical stage (p < 0.001) and type of treatment (p <0.001). Conclusion: The major factor in survival outcome is the ability to completely resect lesion. (Rev Med Hered 1997; 8:129-141)

Keywords : Soft - tissue sarcomas; clinic-pathologic picture; treatment; prognostic factors; long - term survival.

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