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Revista Medica Herediana

versión impresa ISSN 1018-130Xversión On-line ISSN 1729-214X

Resumen

SANCHEZ POVIS, Javier Ernesto; SANDOVAL OKUMA, José Carlos; CONTRERAS CARRENO, Sara Elena  y  CABELLO MORALES, Emilio. Treatment of Graves’ disease with I131. Rev Med Hered [online]. 2006, vol.17, n.1, pp.8-14. ISSN 1018-130X.

Objective: To describe the response and complications in children and teenagers suffering Graves‘ disease who received radioactive iodine therapy. Material and Methods: The clinical records of the patients attended at Paediatric Endocrinology Unit of Hospital Nacional Cayetano Heredia who received therapy with I131 were reviewed. Demographic characteristics, thyroid weight, radioactive iodine uptake, I131 dose and clinical and thyroid function evolution were registered. Results: We include thirteen patients: 1 male and 12 females. The mean thyroid weight obtained was 47.56 +10.70 gr. Initial calculated dose was 3.92 +0.95 mCi, with a total dose of 4.47 +1.66 mCi, and mean following period of 2.76 years. Ten patients received only one dose, 2 patients received two doses and one patient received three doses; all cases remitted. Patients who received only 1 dose showed disease remission at 13.13 weeks and mean remission period of the population was 24.62 weeks. Hypothyroidism prevalence up to six months from initiating treatment was 66.66%, and up to 257 weeks 83.33%. Conclusions: We conclude that I131 was 100% effective in the treatment of children and adolescents suffering Graves’ disease in this small series. (Rev Med Hered 2006;17:8-14).

Palabras clave : Radioiodine; Grave’s disease; hyperthyroidism; children, I131; radioactive iodine- induced hypothyroidism.

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