Resumen

SANCHEZ POVIS, Javier Ernesto; SANDOVAL OKUMA, José Carlos; CONTRERAS CARRENO, Sara Elena  y  CABELLO MORALES, Emilio. Treatment of Graves’ disease with I¹³¹. Rev Med Hered [online]. 2006, vol.17, n.1, pp.8-14. ISSN 1018-130X.

Objective: To describe the response and complications in children and teenagers suffering Graves‘ disease who received radioactive iodine therapy. Material and Methods: The clinical records of the patients attended at Paediatric Endocrinology Unit of Hospital Nacional Cayetano Heredia who received therapy with I¹³¹ were reviewed. Demographic characteristics, thyroid weight, radioactive iodine uptake, I¹³¹ dose and clinical and thyroid function evolution were registered. Results: We include thirteen patients: 1 male and 12 females. The mean thyroid weight obtained was 47.56 +10.70 gr. Initial calculated dose was 3.92 +0.95 mCi, with a total dose of 4.47 +1.66 mCi, and mean following period of 2.76 years. Ten patients received only one dose, 2 patients received two doses and one patient received three doses; all cases remitted. Patients who received only 1 dose showed disease remission at 13.13 weeks and mean remission period of the population was 24.62 weeks. Hypothyroidism prevalence up to six months from initiating treatment was 66.66%, and up to 257 weeks 83.33%. Conclusions: We conclude that I¹³¹ was 100% effective in the treatment of children and adolescents suffering Graves’ disease in this small series. (Rev Med Hered 2006;17:8-14).

Palabras clave : Radioiodine; Grave’s disease; hyperthyroidism; children, I¹³¹; radioactive iodine- induced hypothyroidism.

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