Abstract

TICSE AGUIRRE, Ray et al. Trimethoprim/sulfamethoxazole hypersensibility syndrome: A Case Report. Rev Med Hered [online]. 2006, vol.17, n.2, pp.109-114. ISSN 1018-130X.

27 year old male, admitted to the emergency room with a 3 week history of pruriginous skin rash that began on trunk and then appeared on arms and legs. A week latter patient developed dyspnea and non productive cough. One weak prior to admission patient had desquamative skin lesions, dyspnea at rest and edema on both legs. He had a past medical history of Non-Hodgkin’s B cell lymphoma and Pneumocystis jiroveci, pneumonitis treated with Trimethoprim/sulfamethoxazole 2 month prior to admission. Laboratory test showed leukocytosis  with eosinophilia, cholestatic liver injury and hypoxemia. On chest X-ray the patient had an interstitial pneumonitis. Skin biopsy was positive for drug allergy.  Skin lesions, hematological and systemic compromise defined the diagnosis of Trimethoprim/sulfamethoxazole hypersensibility syndrome. Drug was discontinued and corticosteroid treatment started. Case is discussed and literature was reviewed. (Rev Med Hered 2006;17:109-114).

Keywords : Drug hypersensitivity; sulfonamides; trimethoprim.

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