Revista Medica Herediana
versión On-line ISSN 1729-214X
Nephropathy polyoma virus (NVBK) is being recognized as a major cause of graft failure, usually confused with acute rejection. To date, no cases have been reported in Peru. We report a case of a child's transplant, 17 years old, who presented persistent elevation of serum creatinine in the first month after transplantation. He was treated as acute rejection. Renal biopsy was made. It showed marked tubular epithelial damage with necrosis and partial detachment toward luminal space and presence of atypical cells with little cytoplasm and inclusions intranucleares basophilic, findings consistent with BK virus infection. It was not found signs of rejection. In addition, papanicolao in urine was found Decoy cells. Viral load of BK virus in blood and urine was high. It was discontinued therapy with mycophenolate mofetil, was reduced dose of tacrolimus and began treatment with leflunomide 40 mg/day. Six months after the kidney function of the patient was stabilized, he was staying with creatinine clearance of 30 ml/min/1.73 m2 SC.
Palabras llave : Renal transplantation; polyoma virus infection; child.