Abstract

LEON, Cristian et al. Correlation between 24-hours proteinuria and proteinuria/creatinine rate in aliquots of urine: Value and limitations. Rev Med Hered [online]. 2010, vol.21, n.2, pp.59-64. ISSN 1018-130X.

Objective: To study the correlation between twenty-four hours proteinuria and proteinuria/creatinine index taken from an aliquot of the same sample and analyze the variables that affect the correlation. Methods: 100 people were selected from various adult inpatient and outpatient services from Hospital Nacional Cayetano Heredia who required the measurement of proteinuria in 24 hours for various reasons. Proteinuria and creatinine were measured using auto-analyzers with dry chemistry techniques. Results: One patient was excluded for doubtful collection of the sample. There were 18% male and 82% women. 38% of the sample was pregnant patients. The correlation in the entire sample had an r= 0.74 (p <0.001), demonstrating that the scattering of data occurred in the presence of proteinuria more than 7 g/day; urine volume less than 600 ml/day and pregnant patients. By excluding these data, the correlation had an r= 0.95, p <0.001 (r2 = 0.88, 95% CI 0.79-0.93, p <0.001). Conclusion: There is a high correlation between 24-hours proteinuria and the proteinuria/creatinine index taken from an aliquot. There are critical variables that affect the correlation between these two parameters: doubtful diuresis, great proteinuria and pregnant patients. (Rev Med Hered 2010;21:59-64).

Keywords : Proteinuria; urine creatinine; renal disease.

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