Abstract

MANRIQUE-HURTADO, Helard; ARO-GUARDIA, Pedro  and  PINTO-VALDIVIA, Miguel. Type 2 diabetes in children: Case series. Rev Med Hered [online]. 2015, vol.26, n.1, pp.5-9. ISSN 1018-130X.

Objectives: To describe clinical and biochemical features of children and adolescents with recent onset type 2 diabetes mellitus. Methods: Retrospective study that included children or adolescents with fasting glucose above 126 mg/dl, absence of antiGAD and C peptide above 1.5 ng/dl. Patients with previous diagnosis of type 1 diabetes, diabetes type MODY or drug associated diabetes were excluded. Results: Mean age was 14.3 years; 59% were females, and 43% had at least one parent with type 2 diabetes. At the time of diagnosis, the body mass index was 32.8 kg/m2; 85% had acanthosis nigricans and 68% had Tanner stage IV or V. Initial treatment included oral hypoglycemic drugs in 75% , metformin was the most common drug used (64.3%). Only 41% of cases received insulin. Conclusions: Children and adolescents with type 2 diabetes in this setting have a high frequency of obesity, acanthosis nigricans and family history of type 2 diabetes. In general, these patients have poorly metabolic control and receive metformin as initial treatment.

Keywords : Diabetes mellitus type 2; obesity; insulin resistance; child; adolescent.

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