Abstract

LULLI-CANTONI, Jose Antonio  and  MIYAHIRA, Juan. Frequency of renal sequela after acute uremic hemolytic síndrome. Rev Med Hered [online]. 2015, vol.26, n.2, pp.86-93. ISSN 1018-130X.

Objectives: To determine the frequency of and associated factors to develop renal sequela after an acute episode of hemolytic uremic syndrome (HUS) in children. Methods: A descriptive-retrospective study that evaluated medical charts of patients with HUS at HNCH from 1997 to 2012 was conducted. Clinical features, laboratory findings including renal function tests on admission, discharge and after 6 months of follow-up were retrieved. Patients with incomplete data on renal function tests were contacted to complete the missing information. Results: 7 out of 12 patients presented a reduction in the glomerular filtration rate (GFR), proteinuria or hypertension 6 months or more after the acute episode, with a mean of 30.75 months of follow-up. Factors associated with sequela such as hypertension, proteinuria at discharge, need for dialysis, oligoanuria, leukocytosis > 20 000 cells/mm3 and neurologic symptoms were equally distributed among patients with and without sequela. However, the frequency of proteinuria and oligoanuria were below previously reported rates. Conclusions: Renal sequela does occur after an acute episode of HUS with predicting factors well described in the medical literature.

Keywords : Children; chronic kidney disease; proteinuria; hypertension; glomerular filtration rate; acute renal failure.

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