Abstract

LOVATO, Pedro Eduardo. Acute Myeloid Leukemia in adults: A comparative study of treatment and prognosis by age groups. Rev Med Hered [online]. 2015, vol.26, n.3, pp.160-166. ISSN 1018-130X.

Treatment of acute myeloid leukemia(AML) is based on the administration of chemotherapy (CT), which is associatedwith significant toxicity. The selection of CT is based on age, generalcondition and presence of comorbidities in the patient, with poor prognosisassociated with advanced age. Objective: to compare the clinicaloutcomes of patients with AML treated with CT below 60 years of age with thatof patients above 60 years of age. Methods: A descriptive,retrospective study was carried-out from January 1995 to December 2008 atHospital Edgardo Rebagliaiti. Inclusion criteria wereage above 18 years and to have received CT based on standard protocols by thehospital. Patients with promyelocytic AML and thosein whom a bone marrow transplant had been performed were excluded. Completeremission rate (CRR), persistence rate (PR), mortality rates (MR) and diseasefree survival (DFS) and overall survival (OS) curves were obtained. Results:208 patients were included; 153 were young adults and 55 were older adults,both groups were comparable. CRR, MR and OS were better in young adults, whilePR and OS did not differ by age. Conclusions: Older adultpatients on CT had poor prognosis compared to younger patients. The decision onstaring CT should be individualized balancing the risks and benefits.

Keywords : Acute myeloid leukemia; drug therapy; young adult; senile adult.

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