Abstract

VENTOSILLA, Ronald  and  DEL CARPIO, Daniel. Disseminated histoplasmosis with hemophagocytic syndrome associated with HTLV-1infection: Case report. Rev Med Hered [online]. 2016, vol.27, n.2, pp.100-105. ISSN 1018-130X.  http://dx.doi.org/10.20453/rmh.v27i2.2846.

The hemophagocytic syndrome (HS) is a severe systemic illness ultimately fatal associated with underlying conditions. Histoplasmosis has been associated with HS inimmunosuppressed patients. We present the case of a male patient from Huanuco with a 2-month history of productive cough and presence of interstitial pulmonary infiltrates, and consolidation in the right lower lobe associated with mediastinal lymphadenopathies on the chest x-ray. The patient presented with fever, pancytopenia and abnormalities in the liver and coagulation tests fulfilling criteria for HS. A bone marrow aspiration showed in tracytoplasmicstructures within the macrophages compatible with Histoplasma capsulatum. Serology for HTLV-1 was positive. Weanalyzed the role of HTLV-1 inducing immunosuppression leading to the development of disseminated histoplasmosis and HS.

Keywords : Lymphohistiocytosis; hemophagocytic; hystoplasmosis; human T -lymphotropicvirus 1.

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