Abstract

RUIZ-FERNANDEZ, Nelina Alejandra et al. Exploratory study of the plasmatic markers of redox status and lipidic profile in pregnant adolescents attending public antenatal care service in the city of San Felipe, Venezuela. Rev Med Hered [online]. 2016, vol.27, n.3, pp.121-122. ISSN 1018-130X.

Pregnant adolescents are a group of high biological and social vulnerability. Objective: To evaluate the behavior of plasma markers of redox status and lipid profile in pregnant adolescents in the second and third trimester of pregnancy attending public antenatal care service and compare it with adult pregnant women and non-pregnant women. Methods: Cross-sectional study involving 29 pregnant adolescents (aged 14-20 years), 26 adult pregnant women (aged 20-44 years) and 25 non-pregnant women (aged 17-44 years). Malondialdehyde (MDA), ascorbic acid (AA), uric acid (UA), total cholesterol (TC), LDL cholesterol (LDLc), HDL cholesterol (HDLc), triglycerides (TGL) were determined. Oxidative stress index (MDA/AA), TC/HDLc ratio, LDLc/HDLc ratio, TGL/HDLc ratio and nonHDL-cholesterol were calculated. Results: In both trimesters, pregnant adolescents showed higher levels of MDA, MDA/AA index, TGL, TGL/HDLc ratio and lower concentrations of AA, compared to non-pregnant adolescents. Only in the third trimester, the levls of TC and LDLc of pregnant adolescents significantly exceeded those found in non-pregnant adolescents. The markers did not differ significantly between the second and third trimesters in pregnant adolescents. In the third trimester, the concentrations of MDA, LDLc and nonHDL-cholesterol of pregnant adolescents were significantly lower compared to the adult pregnant women. Conclusions: Normal adolescent pregnancy is associated with changes in the redox state and lipid metabolism, especially in the third trimester, but it was not confirmed that these gestational changes were of greater magnitude relative to the adult pregnant women.

Keywords : adolescent; pregnancy; oxidative stress; ascorbic acid; lipids; uric acid.

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