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Revista Medica Herediana

Print version ISSN 1018-130X


CUBAS, Wildor S  and  PACHECO, Luis G. Diphenylhydantoin-induced toxic epidermal necrolysis: A case report. Rev Med Hered [online]. 2016, vol.27, n.4, pp.247-251. ISSN 1018-130X.

Toxic epidermal necrolysis (TEN) or Lyell´ syndrome and Stevens-Johnson´s syndrome are variants of a same disease sharing pathogenic, histopathological and therapeutic approaches. TEN is an acute and rare presentation and it is considered the most severe dermatologic entity, characterized by blisters, necrosis and sloughing of the dermis. Systemic manifestations are basically respiratory, gastrointestinal and renal; mortality is 70%. TEN is usually druginduced, especially by antiseizure medications including diphenylhydantoin. We present the case of a 60 year-old male treated with diphenylhydantoin for seizures that developed a bullous rash whose clinical presentation; body distribution; systemic involvement and temporal association supported the diagnosis of TEN.

Keywords : Diphenylhydantoin; Stevens-Johnson Syndrome; drug-related side effects and adverse reactions.

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