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Revista Medica Herediana

Print version ISSN 1018-130X


GALLARDO RIOS, María Susana; GARCIA ROJAS, Mariana Andrea  and  SAMALVIDES CUBA, Frine. Comparison of morbimortality of tuberculous meningoencephalitis among immunocompromised and immunocompetent patients in a general hospital. Rev Med Hered [online]. 2017, vol.28, n.1, pp.21-28. ISSN 1018-130X.

Objectives: To compare morbimortality of tuberculous meningoencephalits among immunocompromised and immunocompetent patients in a general hospital. Methods: An observational study was performed reviewing 77 clinical charts of patients diagnosed of tuberculous meningoencephalits between 2005 and 2014. Epidemiological, clinical and laboratory data were gathered. Morbimortality was assessed comparing the neurologic examination on admission and at discharge. A total of 49 immunocompetent and 28 immunosuppressed were evaluated. Results: Males were more affected; mean age was 39.7 ± 18 years. The commonest symptoms on admission were anorexia (82%), headache (77%) and polypnea (66%); 57% were on stage 2, 29 of them (66%) were immunocompetent. At discharge, 75% were on stage1; among patients in grade 4, 28% of deaths occurred in immunosuppressed vs. 72% in immunocompetent, difference that did not reach statistical significance. Headache (p=0.01), fever (p=0.001), nausea (p=0.038) and polypnea (p=0.0005) were more frequent in immunosuppressed patients. Conclusions: This study shows that morbimortality is more common in immunocompetent hosts compared to immunosuppressed hosts.

Keywords : Tuberculous; meningoencephalitis; inmunosuppression; immunocompetence; morbidity; mortality.

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