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Revista Medica Herediana

Print version ISSN 1018-130XOn-line version ISSN 1729-214X


AMARO, Jony  and  IPARRAGUIRRE, María Elena. Effect of the consumption of alfalfa extract (Medicago sativa L.) on the leukocyte count, in mice (Mus musculus). Rev Med Hered [online]. 2018, vol.29, n.2, pp.97-101. ISSN 1018-130X.

Alfalfa, Medicago sativa L, is a highly organic legume, easy to grow and commercialize. In Peru, it is cultivated as fodder for animals. Objectives: To determine the effect of alfalfa extract consumption on the white blood cell count in albino mouse. Methods: Experimental study. carried out in Bioterio of the Facultad de Farmacia y Bioquímica of Universidad Nacional Mayor de San Marcos. Twenty albino mice of the balb / c strain, male, of average weight 23.2 ± 32.8 g were used. Two groups were formed: experimental and control, each of ten mice. The experimental group was administered, orally by cannulation alfalfa extract, in a dose of 250 mg / kg, volume of 2 ml, and the control group, also, orally by cannulation, placebo, volume of 2 ml, every five hours, for a week, alternating with standard nutrients. Leukocyte count was performed. Results: Within the conditioning period, there was a slight increase in leukocytes mean of the control group (3940 ± 1549.3) compared to the experimental group (3840 ± 1468.3), whose difference was not significant. After administering the extract of Medicago sativa L to the experimental group, alternating with their respective nutrients, a significant difference was observed between the mean (7800 ± 2885.2) and the control group (3930 ± 1518.1) (p <0.05). Conclusions: Under experimental conditions, the consumption of Medicago sativa extract significantly increased the number of leukocytes.

Keywords : Medicago sativa; cytokines; immunomodulation; flavonoids; humoral; immunity; cellular.

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