Abstract

FERNANDEZ MERJILDO, Diana; CAYTANO GARCIA, Candy; GALVEZ CANSECO, Aldo  and  GARCIA APAC, Coralith. Colistin toxicity: skin hyperpigmentation, neuro and renal toxicity: A case report. Rev Med Hered [online]. 2018, vol.29, n.4, pp.238-242. ISSN 1018-130X.  http://dx.doi.org/https://doi.org/10.20453/rmh.v29i4.3449.

Colistin or polymycin E is an antibiotic that was discontinued due to its renal and neurologic toxicity related to its colistin sulfate content. These adverse effects have been reduced with the use of sodium colistemathe. There is currently a more frequent use of colistin due to an increase of multi-resistant Gram negative infections, particularly in intensive care units. We present the case of a 50-year-old woman with history of surgery due to gastric perforation, use of steroids and non-steroidal anti-inflammatory drugs, that developed intra-abdominal abscesses due to multidrug resistant Acinetobacter spp. She received 34 days of intravenous colistin and developed skin hyperpigmentation, ataxia and renal failure. These adverse effects disappeared with discontinuation of the drug.

Keywords : Colistin; kidney; toxicity; neurotoxicity syndromes; hyperpigmentation.

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