Abstract

SOTO FONSECA, Marco Antonio; MEDINA RAMIREZ, Katherine Fernanda  and  SANCHEZ BARJUN, Karen. Propylthiouracil induced ANCA positive vasculitis. A case report. Rev Med Hered [online]. 2021, vol.32, n.2, pp.103-107. ISSN 1018-130X.  http://dx.doi.org/10.20453/rmh.v32i2.3983.

ANCA vasculitis associated to propylthiouracil (PTU) is a rare condition with an incidence of 0.47-0.71 cases per 100,000 patients. It affects mainly minor caliber blood vessels. The skin, kidneys and lungs are the organs most affected. To make the diagnosis it is necessary to have a high index of suspicion and rely on histopathologic findings of skin lesions plus a positive ANCA test. Stopping the inducing drug is usually necessary to manage this condition. We report the case of a 45-year-old woman who consumed PTU for two years for the treatment of hyperthyroidism presenting with painful purpuric plaques in the lower limbs.

Keywords : Propylthiouracil; antineutrophil cytoplasmic antibodies; vasculitis.

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