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Revista Estomatológica Herediana
versión impresa ISSN 1019-4355
Resumen
ARTIEDA BARRAGAN, Cristhian David; PALTAS MIRANDA, Mayra Elizabeth y ANDRADE PENAFIEL, Adriana Lucía. Comparison of hyaluronic acid and bee honey on healing and bacterial growth in guinea pig mucosa: in vivo study. Rev. Estomatol. Herediana [online]. 2024, vol.34, n.2, pp.137-145. Epub 29-Jun-2024. ISSN 1019-4355. http://dx.doi.org/10.20453/reh.v34i2.5531.
Objective:
To compare in vivo the topical application of hyaluronic acid and bee honey on healing and bacterial growth in guinea pig mucosa.
Materials and methods:
In vivo study, applied to a sample of 30 guinea pigs, classified in three groups (A, B and C), all with the same conditions (place, feeding and temperature). During five consecutive days, both in the morning and in the afternoon, the following treatments were applied topically: Hyaluronic acid in group A, bee honey in group B, and in group C (control group) no substances were applied. This was carried out using a hypodermic syringe. After sedation, a 4-mm circular incision was made in the guinea pig mucosa in the left infero-lateral region of the incisors. The following characteristics were identified at the wound site: bleeding, edema, erythema (4, 6 and 8 days), scar tissue and presence of suppuration (8 days), and bacterial culture (to measure colony forming units [CFU]).
Results:
The group to which hyaluronic acid was applied in the evolution of the wound showed a decrease in bleeding, edema and erythema; in addition, the formation of scar tissue of 4 mm on the sixth day was 60.00 % (n = 6), there was epithelial union of 80.00 % (n = 8) on the eighth day and showed lower CFU in the analysis ranges.
Conclusion:
Topical application of hyaluronic acid contributes to scar tissue formation, wound closure and decreased bacterial formation.
Palabras clave : Healing; hyaluronic acid; honey; edema; erythema; suppuration.