Abstract

NAKAYAMA, Takamori; MORISHITA, Tetsuo  and  KAMIYA, Toshiaki. Adenomatous Polyposis Coli Gene as a Gatekeeper. Rev. gastroenterol. Perú [online]. 2002, vol.22, n.2, pp.164-167. ISSN 1022-5129.

The Adenomatous Polyposis Coli (APC) Gene is a tumor suppressor gene located in the chromosome 5q21. It has a sequence of 2843 amino acids and a weight of 312 kD. The mutation of the APC gene occurs at the early stages of most sporadic colorectal cancers; and up to 30% in familial adenomatous polyposis. The absence of APC will indicate the inadequate migration of colon mucous cells and its accumulation resulting in polyps formation, which determines a stage in carcinogenicity. An adequate study in prone groups may lead to chemoprophylaxis and/or early treatment of polyps.

Keywords : Colonic polyposis; preneoplastic lesions.