SciELO - Scientific Electronic Library Online

vol.24 issue2Fermentación fecal basal y con lactulosa en pacientes con flatulencia author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Revista de Gastroenterología del Perú

Print version ISSN 1022-5129


AYALA, Elizabeth; FRISANCHO, Oscar  and  CHACON YUPANQUI, Pedro. Cambios histológicos del íleon distal en diarrea crónica asociada con anemia megaloblástica. Rev. gastroenterol. Perú [online]. 2004, vol.24, n.2, pp.117-121. ISSN 1022-5129.

Histological changes of the distal ileum were evaluated in thirteen (13) patients suffering from chronic diarrhea associated with Megaloblastic Anaemia (MA). The patients were seven (7) men and six (6) women with an average age of 55.6 (34-74). They were all diagnosed with MA and treated with cianocobalamin and folic acid, which resulted in fast recovery. Follow up on the patients did not show any other cause related to chronic diarrhea. Biopsies from the distal ileum were taken by colonoscopy. Endoscopy findings were not relevant except for a light paleness or slightly-rough mucose. The following changes were found by examining the histological radiographies: chronic inflammatory infiltration 92% (12), intestinal villous atrophy 62% (8), erosions at villous surface 46% (6), slight ectasia of the lymphatics 46% (6), flattening of the epithelium cells of the villous 38% (5), and focal fibrosis 38% (5). The patients suffering chronic diarrhea associated with MA showed significant changes of the distal intestinal mucose (ileum). Those changes are probably also in the surrounding area and could explain not only the chronic diarrhea, but the poor absorption observed on some of the patients. The quick response to cobalamins and folates treatment showed the important role of these elements in intestinal restoration.

Keywords : megaloblastic anaemia; chronic diarrhea; ileitis; intestinal bacterial overgrowth.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )