Abstract

COZ YATACO, Angel; LOZANO MIRANDA, Adelina; SAMALVIDES CUBA, Frine  and  ANTUNEZ DE MAYOLO RAMIS, Eleazar. Significado del Patrón Serológico "Anti-HBc Aislado" Determinado por la Respuesta Serológica a la Vacunación Contra Hepatitis B. Rev. gastroenterol. Perú [online]. 2005, vol.25, n.3, pp.254-258. ISSN 1022-5129.

Frequently Blood Bank donors are found to have a presence of Total Anti-HBc in the serum in the absence of the Hepatitis B surface antigen (HBsAg) and the Hepatitis B Surface Antigen (Anti-HBs) antibody. This study was designed to determine the serological response to the vaccination against the Hepatitis B virus, and evaluate the effectiveness of the vaccine in such cases, taking into consideration that the protective antibody titers for Hepatitis B are measured in levels above 10 mUl/ml. Thirty-one patients with the HBsAg negative/Anti-HBs negative/Antil-HBc positive serological patterns recieved three doses of the recombinant DNA vaccine (Hepavax Gene 20µg), in a 0,1,2 months vaccination schedule. Anti-HBs levels were taken 30 days after the application of the last dose. After the 3 doses of the vaccine, the Anti-HBs levels were 100mUl/ml in 89% of the cases, 500 in 50% and 1000 in 14,3% of the vaccinated patients. Only 3 patients (9.7%) did not show serological response 30 days after the application of the last dose of the vaccine.  In conclusion, 90% of the patients administered the HBsAg negative/Anti-HBs negative/Anti-HBc positive serological patterns, obtained Anti-HBs levels considered protectors (10mUl/m).

Keywords : Hepatitis B; Isolated Anti-HBc; Serological response; Vaccination.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )