Revista de Gastroenterología del Perú
versión impresa ISSN 1022-5129
MAROCHO, L et al. Estudio comparativo del efecto protector de dos esquemas de inmunización con una vacuna recombinante contra la Hepatitis B en estudiantes del área de ciencias de la salud susceptibles. Rev. gastroenterol. Perú [online]. 2005, vol.25, n.4, pp. 313-319. ISSN 1022-5129.
Objetive: To prove the protector effect of vaccine against hepatitis B in susceptible health sciences students, younger than 30 years old with three schedule of vaccination, two of them are three conventional doses and another one with two doses. Hypothesis: Three schedules of vaccination against hepatitis B produce antibody response over 10 IU/ml Design: This is a analytical, expetimental, longitudinal., prospective and concurrents cohort study. Subjects and Methods: Overall of 100 susceptible medical technology students both sexs from Medicine Faculty of San Marcos University were enlisted; final analysis were done with 89 students.Vaccine doses administred was a HBsAg 20 ug/mL in three schedules: : 0,1 and 6 months, 0,1 and 2 months and 0,1 month and were taken blood samples before and 1,2,6, and 7 months after first doses of vaccine in order to determine anti HBs levels. Results: Final analysis was done in 89 students with 23.5 years old on average; 51.6% were males and 48.3% females. Thirty days after first doses 12.4% of vaccinated were protected, 98.8% after second doses and 100% at 180 days after first doses: Serum antibody levels at the end of study were betwem 532.7 mIU/mL and 1237.2 mIU/ml Conclusions: The results of our study indicate that seven months after first doses of hepatitis B vaccine has a similar seroprotection levels of anti HBs with any of three schedule used. This results seggest that we could be to recomend a two doses schedule for persons younger than 30 years old.
Palabras llave : Hepatitis B; schedule vaccination; two doses; seroprotection.