Abstract

RETO VALIENTE, Luz Victoria; CASTILLO VERGARA, José; PICHILINGUE RETO, Patricia  and  PICHILINGUE PRIETO, Oscar Alfredo. Hepatotoxicidad por Fármacos Antituberculosos en Pediatria. Rev. gastroenterol. Perú [online]. 2005, vol.25, n.4, pp.362-365. ISSN 1022-5129.

The clinical profile of hepatotoxicity induced by tuberculosis drugs varies and the re-introduction of therapy for patients who developed this condition is controversial. 5 pediatric cases treated throughout a period of 10 years in the Pediatric Department of Hipolito Unanue National Hospital are presented. 2 individuals showed an asymptomatic increase of transaminases, 2 individuals had hepatitis, and 1 individual had acute liver failure. Most patients were female school students. Malnutrition and therapy continuation once the hepatic damage was started were found to be the risk factors. A staged reintroduction scheme for these agents after recovery from hepatitis is proposed

Keywords : Hepatotoxicity; antituberculosis drugs; adverse effects.

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