Abstract

CHACALTANA MENDOZA, Alfonso  and  RODRIGUEZ ULLOA, Carlos. Comparative study between manitol 10% and polyetilenglycol in colonoscopic preparation in inpatients of FAP Central Hospital. Rev. gastroenterol. Perú [online]. 2008, vol.28, n.2, pp.125-132. ISSN 1022-5129.

INTRODUCTION: In search alternatives for colonoscopic preparation, we decided to compare the effectiveness, safety and tolerance of the use of 10 % manitol with polyethyleneglycol. METHODS: A prospective, randomized and simple blind study was performed. Eighty consecutive inpatients were prospectively randomized to receive bowel preparation for elective colonoscopy with either 1 liter of 10% manitol (M Group, n=40) or 4 liters of polyethyleneglycol (PEG Group, n=40). Criteria of evaluation were quality of preparation, pre and post preparation laboratory seric test (sodium, potassium, osmolarity) and the presence of undesirable side effects during the preparation.   RESULTS: Both groups were comparable in age, sex and colonoscopic indications. T was no difference between both groups when evaluating the quality of preparation: good or excellent preparation of 87.5 % (manitol Group) and 90 % (PEG Group) (p=0.37). The frequency of adverse effects was minor in group manitol (30 %) that in group PEG (42.5 %), being the nausea the most frequent symptom in both groups. A slight increase in the levels of sodium, potassium and osmolarity serums was found in both groups, without statistical difference or clinical repercussion.   CONCLUSIONS: The preparation for colon cleansing with 10 % manitol is as effective and safe, but better tolerated and accepted than preparation with PEG. 10 % manitol would be a good alternative for colonoscopic preparation, specially for diagnostic procedures.

Keywords : colonic preparation; manitol; polyethyleneglycol.

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