Abstract

RAMIREZ RAMOS, Alberto  and  SANCHEZ SANCHEZ, Rolando. Helicobacter Pylori 25 years after (1983 -2008): epidemiology, microbiology, pathogenics, diagnóstics and treatment. Rev. gastroenterol. Perú [online]. 2009, vol.29, n.2, pp.158-170. ISSN 1022-5129.

Epidemiology: People have been infected by this bacteria 58,000 years ago. Prevalence of infection varies in different nation. In developing countries infection is acquired in early childhood. The forms of infection are/fecal-oral, oral-oral an gastro oral. In Perú we found same prevalence in the coast, jungle and sierra and described that water is one of the ways of infection. Microbiology: Three strains predominant in Spanish, Asiatic and people from India han been identified. ADN has 1.65 million of basis. Different factors of virulence, enzymes and toxins have also been described. Pathogenesis: Inflamatory response; neutrophiles, lifocites T and B, plasma cells, macrophages. Methods of diagnosis: Invasive and non invasive procedures. Therapy: Different treatment schemes are discrebed: 1st, 2nd, 3rd lines, rescue therapies. Secondary reactions, alternative schemes, recurrence, reinfection and experience in Perú are also described.

Keywords : Helicobacter pylori; Epidemiology; Microbiology; Pathogenics; Diagnosis; Treatment.

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