Revista de Gastroenterología del Perú
versión impresa ISSN 1022-5129
BELTRAN GARATE, Brady y YABAR BERROCAL, Alejandro. Expresión de HER2 en cancer gástrico en el Perú: HER2 expression in gastric cancer in Peru. Rev. gastroenterol. Perú [online]. 2010, vol.30, n.4, pp. 324-327. ISSN 1022-5129.
HER2 positivity is thought to be a negative prognostic factor in gastric cancer (GC), correlating with poor survival rates. Reported HER2-positivity rates in GC have varied widely (6-35%).Objetive of this study is to determine rate of positivity and describe clinical and pathological characteristics of HER-2(+) GC. 100 GC tumour samples were centrally screened by immunohistochemistry and FISH. 9% of cases were positive. More positivity HER2 was found in advanced stages (III/IV) vs. early stages (I/II)(p=0.045) ; intestinal histology subtype vs diffuse/ mixed (p=0.045) and gastro-oesophageal junction cancer vs GC ( p=0.005).
Palabras llave : Gastric cancer; prognostic factors; oncogens.