SciELO - Scientific Electronic Library Online

vol.31 issue1Utility of urease rapid test for detection of Helicobacter pylori in patients with upper gastrointestinal bleeding from peptic ulcerHemoconcentration, Apache II and Ranson as early predictors of severity in patients with acute pancreatitis in a hospital in Lima - Peru author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Revista de Gastroenterología del Perú

Print version ISSN 1022-5129


ZEGARRA CHANG, Arturo et al. Pilot study: sequential therapy in erradicating Helicobacter pylori in the Cayetano Heredia Hospital. Rev. gastroenterol. Perú [online]. 2011, vol.31, n.1, pp.21-25. ISSN 1022-5129.

BACKGROUND: Sequential therapy is used as an alternative to growing antibiotic resistance of Helicobacter pylori to the standard triple therapy. Despite the success it had in Europe, we have no information regarding this therapy in our region. OBJECTIVES: To evaluate the eradication rate of Helicobacter pylori using sequential therapy and show its adverse effects. METHODS: We performed a prospective, observational, open descriptive study. 31 patients were evaluated who were treated with sequential therapy in the following way: the first 5 days omeprazole 20 mg and amoxicillin 1 g every 12 hours and following 5 days omeprazole 20 mg, clarithromycin 500 mg and tinidazole 500 mg every 12 hours. After four weeks of treatment, each patient had a C13 urea breath test to check for eradication. RESULTS: 31 patients were included, one patient was excluded from the protocol due to adverse drug react to amoxicillin. Of the remaining 30 patients who completed treatment, 22 (73%) were negative to breath test and 8 (27%) were positive. Of the patients who completed treatment, 10 had minor adverse events to treatment, the main symptoms were epigastralgia and nausea. CONCLUSIONS: Sequential therapy had an eradication rate of 73% which is much lower than that reported in European studies. However, therapy is easily accesible with lower cost and fewer side effects tan standard therapy.

Keywords : sequential therapy; Helicobacter pylori; breath test.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )