Abstract

PADILLA RUIZ, Maykel; FERNANDEZ AGUIAR, María Emilia; ARCE NUNEZ, Merlyn  and  POLO AMORIN, Roberto. Lactobacillus rhamnosus GG supplementation to reduce side-effects of anti-Helicobacter pylori treatment. Rev. gastroenterol. Perú [online]. 2013, vol.33, n.2, pp.121-130. ISSN 1022-5129.

Background: Helicobacter pylori (Hp) eradication fails in about 10% of patients because of the occurrence of resistance to antibiotics and side-effects. During anti H.pylori therapy, probiotics have been used to reduce the incidence of side-effects. Objectives: To determine whether adding the probiotic Lactobacillus rhamhousus GG to an anti-H. pylori regimen could help to prevent or minimize the gastrointestinal side-effect burden. Material and methods: 66 subjects screening positive for H. pylori infection (male/female: 45/21, mean age 56,6 DS ± 16,7 year ), 59 subjects receiving 7 days of Omeprazole 20 mg b.i.d, Amoxicillin 1000 mg b.i.d and Clarithromycin 500 mg b.i.d were randomly assigned to Lactobacillus rhamnosus GG (6 x 10⁹ ufc b.i.d ) (n = 29) or placebo (n = 30). Patients completed questionnaires after the treatment to determine the type and severity of side-effects. Results: Side effects occurred mainly during the eradication therapy; none of them caused therapy discontinuation. Bloating, diarrhea, taste disturbance and epigastric discomfort were the most frequent side effects: (10.3% versus 16%, 13.8% versus 20%, 13.7% versus 20% and 13.7 % versus 20% respectively). No significant differences were found between the two groups for individual symptoms. Conclusion: In this study, probiotic supplementation did not diminish significantly the frequency of new or aggravated symptoms during H. pylori eradication.

Keywords : Probiotics; Lactobacillus rhamnosus; Helicobacter pylori; Drug resistance; bacterial; Side effects.

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