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Revista de Gastroenterología del Perú

Print version ISSN 1022-5129


HINOSTROZA MORALES, Dennis  and  DIAZ FERRER, Javier. Addition of Bismuth subsalicylate to triple eradication therapy for Helicobacter pylori infection: efficiency and adverse events. Rev. gastroenterol. Perú [online]. 2014, vol.34, n.4, pp.315-320. ISSN 1022-5129.

Objectives: To establish the efficiency and adverse effects of the addition of bismuth subsalicylate to triple eradication therapy for Helicobacter pylori infection. Material and methods: Double blind controlled experimental trial. The study population consisted of 54 patients with Helicobacter pylori infection: 29 were allocated to the experimental group, who received the usual triple plus bismuth subsalicylate therapy, and 24 received the triple therapy plus placebo. Results: The average age was 47+-14.9 years, 66.7% of the patients were women. Both groups underwent the breath test: it was negative in 89.7% of the patients from the experimental group and 80% of the patients from the placebo group (p=0.319). The adverse events of both groups were: diarrhea (10.3% in the experimental group vs 16% in the placebo group; p=0.537), dark feces (37.9% in the experimental group vs 0% in the placebo group; p=0.001), abdominal pain (20.7% in the experimental group vs 52% in the placebo group; p=0.016). Nausea only were present in 3% of the patients of placebo group p=0.055). Conclusions: The association of bismuth subsalicylate to the triple therapy scheme for the erradication of Helicobacter pylori was effective in 89.7% of patients, whereas 80% of efficiency was obtained in the placebo group (p=0.319). The adverse events were lesser in the experimental group.

Keywords : Bismuth; Helicobacter pylori; treatment; infection.

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