SciELO - Scientific Electronic Library Online

vol.36 issue3Sphincterotomy followed by papillary large balloon in the management of cholecolithiasis: Therapeutic success and safety in a Lima-Peru hospital author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO


Revista de Gastroenterología del Perú

Print version ISSN 1022-5129


SILVA-DIAZ, Heber et al. Frequency and in vitro susceptibility antiparasitic of Blastocystis hominis from patients admitted to the Hospital Regional Lambayeque, Peru. Rev. gastroenterol. Perú [online]. 2016, vol.36, n.3, pp.197-202. ISSN 1022-5129.

Objective. To describe the frequency and antiparasitic in vitro susceptibility of Blastocystis hominis in patients admitted to the Hospital Regional Lambayeque, Peru. Material and methods. A cross-sectional study was conducted from January to August 2015 at 313 patients of all ages. B. hominis detection was performed on serial fecal samples by direct microscopic examination and microculture in modified Locke solution. The in vitro susceptibility testing against the drug metronidazole, nitazoxanide, trimethoprim-sulfamethoxazole and erythromycin was performed in 24 strains of B. hominis, which grew up (microculture method) in 10 double concentrations of each antimicrobial (from 256 ug/ml to 0.5 ug/mL) plus a control. Results. 46.3% (145/313) of the sample had B. hominis, also the age between 12 to 17 years and 60 years was associated with higher frequency of parasites (OR: 2.93 and 2.62). The minimum inhibitory concentration (MIC) 90 of metronidazole and nitazoxanide was 3.19 ug/mL and 11.19 ug/ml, respectively, whereas the MIC 90 of trimethoprim-sulfamethoxazole and erythromycin were above 256 ug/mL. Conclusions. B. hominis occurs in high frequency in patients admitted to the Hospital Regional in Lambayeque, proving to be an important problem of public health in the region. Also B. hominis isolated from these patients were shown to be susceptible in vitro to low concentrations of metronidazole and nitazoxanide so they could be chosen for treatment of this parasite.

Keywords : Blastocystis hominis; Metronidazole; Sulfamethoxazole drug combination; Erythromycin.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )