Abstract

ROLDAN-RODRIGUEZ, Aníbal Enrique et al. Gastroprotective effect of honey in Holtzman rats with piroxicam-induced gastric ulcer. Rev. gastroenterol. Perú [online]. 2016, vol.36, n.3, pp.219-224. ISSN 1022-5129.

Objective: To determine the effect of treatment with honey in piroxicam-induced gastric ulcer in Holtzman rats. Materials and methods: 48 eight-week old female Holtzman rats, weights between 100 and 200 grams, were divided into 6 treatment groups as follow: Group A: water; Group B: piroxicam (30 mg/kg); Group C: omeprazole (5 mg/kg) and piroxicam (30 mg/kg); Group D: honey (2.5 g/kg) and piroxicam (30 mg/kg); Group E: honey (5 g/kg) and piroxicam (30 mg/kg); Group F: honey (7.5 g/kg) and piroxicam (30 mg/kg). Macroscopic studies, using Scion Image, and microscopic histological section of gastric mucosa were performed after the interventions. Results: The results of the macroscopic studies showed statistically significant differences for both doses of honey at 6 g/kg and 7.5 g/kg when compared to piroxicam (p=0.016 and p=0.001 respectively) and the gastroprotective effect was similar when compared to omeprazole (p>0.05). Microscopic studies showed statistically significant differences only for dose at 7.5 g/kg when compared to piroxicam (p=0.0018) and the gastroprotective effect was similar to omeprazole (p=1). Conclusion: Dose of honey at 7.5 g/kg showed gastroprotective effect at microscopic and macroscopic studies when compared to omeprazole.

Keywords : Stomach ulcer; Piroxicam; Rats.

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