SciELO - Scientific Electronic Library Online

 
vol.38 issue1Helicobacter pylori: How do we treat it in 2018?Endoscopic submucosal dissection of a transpyloric early gastric cáncer: A case report and literature review author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO

Share


Revista de Gastroenterología del Perú

Print version ISSN 1022-5129

Abstract

RODRIGUEZ LUGO, Diego Andrés; CORONADO TOVAR, Jorge Julián; SOLANO VILLAMARIN, Giovana Alejandra  and  OTERO REGINO, Wiliam. Primary Biliary Cholangitis. Part 2. State of the Art, Diagnosis, Associated Diseases, Treatment and Prognosis. Rev. gastroenterol. Perú [online]. 2018, vol.38, n.1, pp.64-71. ISSN 1022-5129.

Primary biliary cholangitis (PBC) is a chronic autoimmune cholangiopathy characterized by a selective destruction of biliary epithelial cells of small and medium caliber hepatic ducts, which mainly affects women. The main symptoms are fatigue and pruritus, however, a large proportion of patients may be asymptomatic. The diagnosis is based on AMA titers >1:40, alkaline phosphatase >1.5 times the upper limit for more than 24 weeks and compatible liver histology. It is associated with multiple autoimmune diseases mainly extrahepatic, thyroid diseases, bone diseases, among others. The first line treatment is ursodeoxycholic acid (UDCA), that improves liver function tests and delay the progression to cirrhosis. Currently, there are new treatments and adjuvant therapies on study. The purpose of this review is to offer an update in this topic, which is very important in gastroenterology and internal medicine. We formed an interdisciplinary team to search in the data base Medline thorough PubMed with the keywords describe below, we made a critical lecture of the titles and abstracts of each article to write this paper

Keywords : Cholangitis; Cirrhosis; Pruritus; Jaundice.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License