Abstract

MARULANDA, Hernando; OTERO, William  and  GOMEZ, Martín. Helicobacter pylori, nodular gastritis and premalignant stomach lesions: a case-control study. Rev. gastroenterol. Perú [online]. 2018, vol.38, n.4, pp.349-355. ISSN 1022-5129.

Introduction: Nodular gastritis (GN) is a type of gastritis strongly related to Helicobacter pylori and may be a risk factor for gastric cancer. It is a highly prevalent pathology in children infected with H. pylori. In Colombia there are no studies on this entity and for this reason we decided to carry out the present investigation. Materials and methods: Case studies and controls. Case; endoscopic and histological nodular gastritis, controls, chronic gastritis without lymphoid follicles to histology. Population: adults older than 18 years, who underwent a high digestive endoscopy and signed informed consent. All patients were biopsied with the OLGA system. Results: We included 344 patients, 172 in each group. The cases had 10 years less than the controls (40.9 vs 50.9, p = 0.045). In the cases H. pylori was found in 91.9% vs 47.8% (p <0.001). Lymphoid follicles were more frequent in the antrum than in the body (60.5 vs 4.7% p < 0.00001). OLGA II in cases 6.4% versus 1.2% (p = 0.01), OLGA III was similar. There was no OLGA IV in any patient. In the cases a gastric cancer was found. Conclusions: Patients with nodular gastritis are younger than controls. 92% of the cases had H. pylori. Recommendations: It is recommended that this infection be investigated and eradicated in patients with this type of gastritis.

Keywords : Helicobacter pylori; Gastritis; Stomach Neoplasms.

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