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Revista de Gastroenterología del Perú
versão impressa ISSN 1022-5129
Resumo
ICHIYANAGUI R, Carlos; SORIANO A, César e FRISANCHO V, Oscar. Efficacy and safety of lyophilized concentrate purple corn (Zea mays L.) in preventing the formation of colonic polyps. Rev. gastroenterol. Perú [online]. 2021, vol.41, n.3, pp.156-163. ISSN 1022-5129. http://dx.doi.org/10.47892/rgp.2021.413.1308.
Introduction
: Colorectal cancer (CRC) is a worldwide problem of public health and arises mainly from polyps. In last 25 years, a strategy called chemoprevention that consists of food intake like purple corn and turmeric or chemical substances like acetyl salicylic acid (ASA) and non-steroidal anti-inflammatory drugs (NSAIDs) that prevent effectively carcinogenesis reducing the risk of polyp development.
Objective
: To determine the efficacy and safety of lyophilized concentrate of purple corn (Zea mays L.) 200 mg in the prevention of colonic polyps development in private gastroenterological practice
Methods
: we randomly assigned 112 patients (cases) to receive this product and 112 patients (controls) to receive placebo, during 3 years. Both groups had similar demographic, clinical and medical history characteristics.
Results
: we found that cases developed 83% less polyps than controls (p<0.001). The cases that developed polyps were smaller in number, size and histology than at the beginning of the trial. The adverse events that cases presented were 4.5% similar to controls, mainly petechiae.
Conclusion
: We conclude that the lyophilized concentrate of purple corn (Zea mays L.) 200 mg was effective and safe in preventing the development of colonic polyps.
Palavras-chave : Chemoprevention; Colorectal cancer; Zea mays; Colonic polyps.